Detection of Methylhexaneamine and other Stimulants in UK Supplement Products

LGC Methylhexanamine White Paper - Informed

Methylhexaneamine is a stimulant originally developed for use as a nasal decongestant in 1944. Although voluntarily withdrawn from medical use, methylhexaneamine later resurfaced as an ingredient within a wide range of weight management (fat burning) and/or energy-boosting supplements. After methylhexaneamine consumption was linked to a number of adverse health incidents, including fatalities, the US Food and Drug Administration (FDA) and UK Medicines and Healthcare products Regulatory Agency (MHRA) took steps to prohibit the use of this compound within dietary supplements. In 2010, the World Anti-Doping Agency (WADA) listed methylhexaneamine as a banned substance and it remains prohibited for use by athletes.

Despite the steps taken by the FDA, MHRA and sporting bodies such as WADA, products containing these substances are still widely available on the market place and there continue to be incidences of athletes testing positive for prohibited stimulants.

Download our Continued Detection of Methylhexaneamine and other Aliphatic Amine Stimulants in UK Supplement Products white paper that details:
  • An experiment, performed by LGC, analyzing 28 samples from the U.K. 
  • The Liquid Chromatography High-Resolution Accurate Mass (HRAM) Mass Spectrometry. 
  • The prevalence of methylhexaneamine and structurally similar compounds within UK supplement products. 
  • The importance of label verification and third-party testing.